|
|
lithocholic_acid + NAD+ <=> 3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
–
|
| |
BRENDA:
BR29316
KEGG:
R04139
MetaCyc:
1.1.1.52-RXN
SABIO-RK:
3860
|
|
|
|
3-dehydrocholoyl-CoA + NAD+ <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
|
1.3.1.115
3-oxocholoyl-CoA 4-desaturase
|
–
|
| |
BRENDA:
BR52278
KEGG:
R12109
MetaCyc:
BAI3OXO-OXRED-RXN
|
|
|
|
12-alpha-hydroxy-3_oxochol-4-enoate + NAD+ <=> 12alpha-hydroxy-3-oxocholate-4,6-dienoate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-19429
|
|
|
|
choloyl-CoA + NAD+ <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
|
1.3.1.115
3-oxocholoyl-CoA 4-desaturase
|
–
|
| |
BRENDA:
BR52277
KEGG:
R12110
MetaCyc:
RXN-17400
|
|
|
|
3-oxochol-4-en-24-oate + NAD+ <=> 3-oxochola-4,6-dien-24-oate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-21340
|
|
|
|
deoxycholate + NAD+ <=> 12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1
1.1.1.392
3alpha-hydroxycholanate dehydrogenase (NADP+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
|
| |
BRENDA:
BS188317
MetaCyc:
RXN-17396;
RXN-21337_WOP
|
|
|
|
choloyl-CoA + NAD+ <=> 3-dehydrocholoyl-CoA + NADH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.395
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
|
–
–
|
| |
BRENDA:
BS230635-a
MetaCyc:
BAIAEUBSP-RXN
|
|
|
|
ATP + chenodeoxycholic_acid + CoA <=> AMP + diphosphate + chenodeoxycholoyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
BRENDA:
BS345
KEGG:
R08743
MetaCyc:
RXN-17398
|
|
|
|
ATP + cholic_acid + CoA <=> AMP + diphosphate + choloyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
| |
BRENDA:
BR90
KEGG:
R02794
MetaCyc:
CHOLATE--COA-LIGASE-RXN
|
|
|
|
7alpha-hydroxy-3-oxochol-4-enoate <=> 3-oxochola-4,6-dien-24-oate + H2O
|
4.2.1.106
bile-acid 7alpha-dehydratase
|
–
|
| |
BRENDA:
BS433347
MetaCyc:
RXN-21339
|
|
|
|
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate <=> 12alpha-hydroxy-3-oxocholate-4,6-dienoate + H2O
|
4.2.1.106
bile-acid 7alpha-dehydratase
|
–
|
| |
BRENDA:
BS375014
KEGG:
R07318
MetaCyc:
RXN-21336
SABIO-RK:
8493
|
|
|
|
12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic_acid + NAD+ <=> 12-alpha-hydroxy-3_oxochol-4-enoate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-19428
|
|
|
|
3-oxo-5beta-cholan-24-oic_acid + NAD+ <=> 3-oxochol-4-en-24-oate + NADH + H+
|
1.3.1.114
3-dehydro-bile acid Delta4,6-reductase
|
–
|
| |
MetaCyc:
RXN-21341
|
|
|
|
7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> 7alpha-hydroxy-3-oxochol-4-enoate + choloyl-CoA
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21338
|
|
|
|
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate + choloyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
| |
MetaCyc:
RXN-21335
|
|
|
|
chenodeoxycholoyl-CoA + NAD+ <=> choloyl-CoA + NADH + H+
|
1.1.1.395
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
|
–
|
| |
MetaCyc:
RXN-17399
|
|
